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Reverse Osmosis

 

System description
Reverse osmosis (RO) is a technology based on a semi-permeable membrane that is permeable to the water but impermeabile to other substances as salts, endotoxins and bacteria. Click on picture to enlarge   Reverse osmosis membrane salt removal is over (>99,5%), the double pass RO configuration is able to guarantee with high reliability the compliance with the Pharmacopoeias requirements.
Application


Pharmaceutical Water

USP: PW, WFI

EU Ph: PW


Reverse osmosis double pass is widely used for the production of non-compendial  and compendial Purified Water (PW) meeting the USP and European Pharmacopoeia requirements, more then 200 ELETTRACQUA Reverse Osmosis system has been sucessfully validated across the world.


 

Pharmaceutical RO construction features

Each ELETTRACQUA plant is “tailor made” to meet the different specificity of our customers requirements, or starting from customer room lay out to have the best installation solution.


Frame: AISI 304

Piping and fittings: AISI 316L ASME BPE

Connections: Tri-clamp

Membrane Housings: AISI 316L

Valves: AISI 316L

Sanitization

ELETTRACQUA Reverse osmosis sanitization options are:

Chemical sanitization

Hot water sanitization

sanitization_options

 

Hot Water sanitization

Elettracqua high temperature RO are sanitized with hot water (> 80°C), having several advantages than chemical sanitization:


  • Sanitization process fully automatic managed by PLC with continuous monitoring of sanitization temperatures
  • Semplified validation of the thermal process
  • Reliable process
  • No need to prove the chemical rinse out

Compliance

CGMP

USP PW, WFI
EU Pharmacopoeia

ISPE Baseline Guide

GAMP

 

 
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